Description

UbiquiTx is a stealth biotech company pioneering the next generation of targeted protein modulators. We are designing a novel class of therapeutics that potently and selectively modulate historically undruggable targets not currently addressable by small-molecule degraders utilizing computationally-designed protein fusions that can both bind to a target of interest and tag it for targeted intracellular modulation. 

UbiquiTx is seeking a highly motivated, creative and solutions-oriented Associate Scientist to join its therapeutic discovery team located in Cambridge, MA. As a member of an interdisciplinary team, this individual will support key aspects of biological assays, pre-clinical studies, platform and research programs for the development of UbiquiTx’s programs and future pipeline product candidates. In this hands-on laboratory position, the successful candidate will contribute to the preclinical discovery, development and assessment of UbiquiTx’s novel platform. In particular, the applicant should have experience in mammalian cell culturing techniques, molecular biology, and in vitro assay development. The applicant is expected to have a robust experimental skill set, an eagerness for learning, and contribute to a strong culture of teamwork and collaboration in a fast-paced environment.

Primary responsibilities will include:

      Maintain and passage mammalian cell lines, including routine health monitoring, mycoplasma testing, and cryopreservation 

      Execute cell-based assays including viability, and functional assays with consistency and attention to detail 

      Retroviral or lentiviral transduction of cell lines and expression validation; protein/antibody expression, qPCR, and flow cytometry  

      Help manage day-to-day lab operations including ordering supplies, maintaining equipment logs, managing inventory, and ensuring common areas and cell culture              facilities are organized and compliant with safety standards 

      Assist with general lab maintenance including autoclave runs, waste disposal, and routine equipment maintenance and troubleshooting 

      Generate, analyze, and communicate data in a timely manner via scientific presentations or written reports

      Follow experimental protocols accurately and help establishing SOPs  

      Build and maintain relationships with vendors and assist with technical aspects of vendor communications 

      Actively contribute to a collaborative, team-oriented atmosphere and assist colleagues as needed 

      Maintain high standards of laboratory safety

Requirements

      Hands-on experience in mammalian cell culture — candidates should be comfortable independently maintaining multiple cell lines in a fast-paced environment

       The applicant is expected to have an eagerness for learning, and contribute to a strong culture of teamwork and collaboration in a fast-paced environment
      MS/BS in Biology with a minimum of 2 years relevant laboratory experience

      Experience with in vitro cell-based assays

      Ability to work independently and able to balance multiple tasks or projects

      Ability to follow detailed protocols  

      Strong organizational skills and attention to detail; diligent experimental record keeping using an ELN system 

      Ability to manage lab supplies and contribute to the operational upkeep of a shared research facility 

      Collaborative, reliable, and positive attitude; comfortable balancing multiple tasks in a dynamic environment

      Collaborative, and proactive